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Trazodone is available as an extended-release or regular release oral tabletThe tablets should not be chewed or crushedThey may be broken in halfdepending on dose prescribed by your doctor.

Prescribers or other health professionals should inform patientstheir familiesand their caregivers about the benefits and risks associated with treatment with Desyrel and should counsel them in its appropriate useA patient Medication Guide About Using Antidepressants in Children and Teenagers is available for DesyrelThe order benemid probenecid prescriber or health professional should instruct patientstheir familiesand their caregivers to read the Medication Guide and should assist them in understanding its contentsPatients should be given the opportunity to discuss the contents of the Medication Guide and to obtain answers to any questions they may haveThe complete text of the Medication Guide is reprinted at the end of this document.

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A major depressive episode may be the initial presentation of bipolar disorderIt is generally believedthough not established in controlled trialsthat treating such an episode with an antidepressant alone may increase the likelihood of precipitation of a mixed/manic episode in patients at risk for bipolar disorderWhether any of the symptoms described above represent such a conversion is unknownHoweverprior to initiating treatment with an antidepressantpatients with depressive symptoms should be adequately screened to determine if they are at risk for bipolar disordersuch screening should include a detailed psychiatric historyincluding a family history of suicidebipolar disorderand depressionIt should be noted that Desyrel is not approved for use in treating bipolar depression.

The figures cited cannot be used to predict precisely the incidence of untoward events in the course of usual medical practice where patient characteristics and other factors often differ from those which prevailed in the clinical trialsThese incidence figuresalsocannot be compared with those obtained from other clinical studies involving related drug products and placebo as each group of drug trials is conducted under a different set of conditions.

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